Second-generation pterocarpanquinones: synthesis and antileishmanial activity
نویسندگان
چکیده
منابع مشابه
Synthesis of 2-methoxybenzoylhydrazone and evaluation of their antileishmanial activity.
Compounds 1-25 showed varying degree of antileishmanial activities with IC50 values ranging between 1.95 and 88.56 μM. Compounds 2, 10, and 11 (IC50=3.29±0.07 μM, 1.95±0.04 μM, and 2.49±0.03 μM, respectively) were found to be more active than standard pentamidine (IC50=5.09±0.04 μM). Compounds 7 (IC50=7.64±0.1 μM), 8 (IC50=13.17±0.46 μM), 18 (IC50=13.15±0.02 μM), and 24 (IC50=15.65±0.41 μM) exh...
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ژورنال
عنوان ژورنال: Journal of Venomous Animals and Toxins including Tropical Diseases
سال: 2018
ISSN: 1678-9199
DOI: 10.1186/s40409-018-0174-7